Cancer Terms

Interferon Gamma Receptor Beta Chain

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Interferon Gamma Receptor Beta Chain

Interferon Gamma Receptor Beta Chain Definition

Encoded by human IFNGR2 Gene (Type II Cytokine Receptor Family), 337-aa 38-kDa (precursor) type I membrane protein Interferon Gamma Receptor Beta Chain is an integral accessory factor subunit of Interferon Gamma Receptor Complex required for signal transduction. Ser/Thr phosphorylated IFN Gamma Receptor activates macrophages in innate immune responses to viral infection and host defenses. Ligand-bound receptor activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain. Containing 2 fibronectin type III domains, IFNGR2 may interact with GAF, JAK1, and/or JAK2. (NCI)

Interferon Gamma Receptor Beta Chain Synonyms

Interferon Gamma Receptor Beta Chain, AF-1, IFGR2, Interferon Gamma Receptor Accessory Factor-1, Interferon Gamma Receptor-2, Interferon Gamma Transducer-1

Terms in Interferon Gamma Receptor Beta Chain category



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