Cancer Terms

Interleukin-1-Alpha

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Interleukin-1-Alpha Definition

Interleukin-1-Alpha is one of two distinct forms of IL1 encoded by separate genes. IL1(alpha) is the acidic form and IL1(beta) is the neutral form. Synthesized by many cells including activated macrophages, keratinocytes, stimulated B-lymphocytes, and fibroblasts, IL1A and IL1B are potent mediators of inflammation and immunity. Both forms, but particularly IL1B, are expressed in polymorphonuclear leukocytes stimulated with LPS. Both IL1A and IL1B are potent bone resorbing factors. Interleukin-1 is also involved in apoptosis. Both IL1 forms are released as a consequence of cell injury. (from OMIM 147760 and NCI)

Interleukin-1-Alpha Synonyms

Interleukin-1-Alpha, Hematopoietin-1, IL-1-a, IL-1A, IL-1alpha, IL1, IL1-Alpha, IL1A, IL1A Protein, IL1F1, Interleukin 1, Alpha, Interleukin 1-Alpha, Preinterleukin 1 Alpha, interleukin-1-alpha

Terms in Interleukin-1-Alpha category



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