Interleukin-12A
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Interleukin-12A Definition
IL12A (p35) comprises one chain of the heterodimeric IL12. Interleukin-12 is a novel cytokine cloned from B-cell lines. It has a broad array of potent biologic activities, acting at picomolar and subpicomolar levels on both T and NK cells. It stimulates the production of interferon gamma from T-cells and natural killer cells and also induces differentiation of TH1 cells. Sequence comparisons showed that p35 is related in sequence to ligands of the cytokine receptor family, most closely to IL6 and GCSF. On the other hand, p40 is a member of the cytokine receptor family, most closely related to IL6R, and forms a subgroup with IL6R and GCSFR. (from OMIM 161560)
Interleukin-12A Synonyms
Interleukin-12A, CLMF, CLMF p35, Cytotoxic Lymphocyte Maturation Factor, Cytotoxic Lymphocyte Maturation Factor 1, p35, Cytotoxic Lymphocyte Maturation Factor 35 kDa Subunit, IL-12, subunit p35, IL-12A, IL12, Subunit P35, IL12A, IL12A Protein, Interleukin 12A, Interleukin 12A (Natural Killer Cell Stimulatory Factor 1, Cytotoxic Lymphocyte Maturation Factor 1, p35), Interleukin 12A Precursor, Interleukin-12 Alpha Chain, Interleukin-12 Alpha Chain Precursor, NF Cell Stimulatory Factor Chain 1, NFSK, NKSF1, Natural Killer Cell Stimulatory Factor 1, 35 kD Subunit, Natural Killer Cell Stimulatory Factor, 35-kD Subunit, interleukin 12, p35
Terms in Interleukin-12A category
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