Interleukin-12B
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Interleukin-12B Definition
IL12B (p40) comprises one chain of the heterodimeric IL12. Interleukin-12 is a novel cytokine cloned from B-cell lines. It has a broad array of potent biologic activities, acting at picomolar and subpicomolar levels on both T and NK cells. It stimulates the production of interferon gamma from T-cells and natural killer cells and also induces differentiation of TH1 cells. Sequence comparisons showed that p40 is a member of the cytokine receptor family, most closely related to IL6R, and forms a subgroup with IL6R and GCSFR. On the other hand, p35 is related in sequence to ligands of the cytokine receptor family, most closely to IL6 and GCSF. (from OMIM 161560)
Interleukin-12B Synonyms
Interleukin-12B, Cytotoxic Lymphocyte Maturation Factor 2, p40, IL12B, IL23, subunit p40, Interkeukin-12 beta chain, Interleukin 12, p40, Interleukin 12B, Natural Killer Cell Stimulatory Factor-2
Terms in Interleukin-12B category
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