Interleukin-13

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Cytokine -> Interleukin -> Interleukin-13

Interleukin-13 Definition

Interleukin-13, encoded by the IL13 gene, is an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. Interleukin-13 is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. (From LocusLink)

Interleukin-13 Synonyms

Interleukin-13, IL-13, IL13, Interleukin 13

Interleukin-13

Interleukin-13 Definition

Interleukin-13 Synonyms

Terms in Interleukin-13 category