Interleukin-15
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Interleukin-15 Definition
Interleukin-15, encoded by the IL15 gene, is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukin 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Three alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. (From LocusLink)
Interleukin-15 Synonyms
Interleukin-15, IL-15, IL15, IL15 Protein, Interleukin 15, Interleukin-15 Precursor, MGC9721
Terms in Interleukin-15 category
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