Cancer Terms

Interleukin-7 Receptor

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Ligand Binding Protein -> Receptor -> Cell Surface Receptor -> Cytokine Receptor -> Interleukin-7 Receptor

Interleukin-7 Receptor Definition

This protein is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor common gamma chain (IL2RG). It has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). (from LocusLink)

Interleukin-7 Receptor Synonyms

Interleukin 7 Receptor, CD127, IL7R, Interleukin 7 Receptor Alpha

Terms in Interleukin-7 Receptor category



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