Irinotecan
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Camptothecin Analogue -> Irinotecan
Irinotecan Definition
The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.
Irinotecan Synonyms
Irinotecan Hydrochloride, CPT 11, CPT-11, Campto, Camptosar, Camptothecin 11, Camptothecin-11, IRINOTECAN HYDROCHLORIDE, U-101440E
Terms in Irinotecan category
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