Irinotecan Base

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Topoisomerase Inhibitor -> Topoisomerase-I Inhibitor -> Camptothecin Analogue -> Irinotecan Base

Irinotecan Base Definition

A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

Irinotecan Base Synonyms

Irinotecan, (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione, (+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin, IRINOTECAN, [1,4'-bipiperidine]-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, irinotecan

Irinotecan Base

Irinotecan Base Definition

Irinotecan Base Synonyms

Terms in Irinotecan Base category