Janus Kinase-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Protein Tyrosine Kinase -> Janus Kinase-1

Janus Kinase-1 Definition

Janus kinase 1 (JAK1), is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. (from LocusLink)

Janus Kinase-1 Synonyms

Janus Kinase 1, EC 2.7.1.112, JAK1, Tyrosine-Protein Kinase JAK1

Janus Kinase-1

Janus Kinase-1 Definition

Janus Kinase-1 Synonyms

Terms in Janus Kinase-1 category