Karenitecin
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Camptothecin Analogue -> Karenitecin
Karenitecin Definition
A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Karenitecin stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, karenitecin exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins. (NCI04)
Karenitecin Synonyms
Cositecan, (4S)-4-Ethyl-4-hydroxy-11-(2-(trimethylsilyl)ethyl)-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione, BNP1350, COSITECAN, DB 172, Karenitecin, karenitecin
Terms in Karenitecin category
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