Cancer Terms

KiSS1 Metastasis Suppressor Protein

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KiSS1 Metastasis Suppressor Protein Definition

Encoded by human KISS1 Gene, the 145-amino acid 15 kD KISS1 Metastasis Suppressor Protein may regulate events downstream of cell-matrix adhesion, perhaps cytoskeletal reorganization. Expressed in placenta, pancreas, and kidney, KISS1 may suppress metastasis without affecting tumorigenicity. Metastin, a placental truncated C-terminally amidated peptide form of KISS1, with 54 amino acid residues, is an endogenous ligand of orphan GPR54 (GPCR) and appears to inhibit chemotaxis and metastasis. (NCI)

KiSS1 Metastasis Suppressor Protein Synonyms

KiSS1 Metastasis Suppressor Protein, KISS1, KISS1 Metastasis Suppressor, Malignant Melanoma Metastasis-Suppressor, Malignant Melanoma Metastasis-Suppressor KiSS-1

Terms in KiSS1 Metastasis Suppressor Protein category



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