LIM Domain Kinase-1
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Serine-Threonine Protein Kinase -> LIM Domain Kinase-1
LIM Domain Kinase-1 Definition
LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Two splice variants have been identified. (LocusLink)
LIM Domain Kinase-1 Synonyms
LIM Domain Kinase 1, EC 2.7.1.37, LIM KINASE, LIMK-1, LIMK1
Terms in LIM Domain Kinase-1 category
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