LY2181308
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LY2181308 Definition
A second-generation antisense oligonucleotide against survivin mRNA with potential antitumor activity. Oligonucleotide LY2181308 hybridizes to survivin mRNA, thereby blocking translation of survivin protein, a member of the inhibitor of apoptosis (IAP) family. Survivin, expressed during embryonal development, is upregulated in a variety of human cancers while absent in most normal adult cells; its expression in tumors is associated with a more aggressive phenotype, shorter survival times, and a decreased response to chemotherapy. Silencing expression of survivin potentially leads to restoration of the apoptotic process in cancer cells, thereby facilitating chemotherapeutic treatments.
LY2181308 Synonyms
Antisurvivin Antisense Oligonucleotide LY2181308, LY2181308
Terms in LY2181308 category
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