Lapatinib Ditosylate
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Lapatinib Ditosylate Definition
The ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.
Lapatinib Ditosylate Synonyms
Lapatinib Ditosylate, LAPATINIB DITOSYLATE, Tykerb
Terms in Lapatinib Ditosylate category
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