Left-Right Determination Factor-B
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Transforming Growth Factor-Beta -> Left-Right Determination Factor-B
Left-Right Determination Factor-B Definition
Containing a TGF-beta family domain, similar to LEFTYA, and encoded by human LEFTB Gene (TGF-Beta Family), secreted 366-amino acid 41-kD Left-Right Determination Factor B (preproprotein) undergoes cell-specific alternative processing into three different products. Processing may occur at R-X-X-R sites. LEFTB appears required for left-right determination during early presomite development in mammals. It may serve as a feedback inhibitor to restrict the range of nodal signaling during establishment of the axis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Left-Right Determination Factor-B Synonyms
Left-Right Determination Factor B, LEFTB, Left-Right Determination Factor B Preproprotein, Lefty 2 Homolog, Lefty-B Protein
Terms in Left-Right Determination Factor-B category
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