Lepirudin
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Agent Affecting Blood And Body Fluid ->
Anticoagulant Agent -> Lepirudin
Lepirudin Definition
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis.
Lepirudin Synonyms
Lepirudin, LEPIRUDIN, Recombinant Hirudin, Refludan, lepirudin
Terms in Lepirudin category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.