Cancer Terms

Lestaurtinib

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Protein Kinase Inhibitor -> Tyrosine Kinase Inhibitor -> Lestaurtinib

Lestaurtinib Definition

An orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. (NCI05)

Lestaurtinib Synonyms

Lestaurtinib, 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-, CEP-701, KT-5555, LESTAURTINIB, SPM-924

Terms in Lestaurtinib category



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