Liarozole Hydrochloride
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Enzyme Inhibitor ->
Aromatase Inhibitor ->
Non-Steroidal Aromatase Inhibitor -> Liarozole Hydrochloride
Liarozole Hydrochloride Definition
The fumarate salt of an orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.
Liarozole Hydrochloride Synonyms
Liarozole Hydrochloride, (+-)-5-(m-Chloro-alpha-imidazol-1-ylbenzyl)benzimidazole Monohydrochloride, 1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-, Monohydrochloride, (+-)-, LIAROZOLE HYDROCHLORIDE, Liarozole HCl, R 75251
Terms in Liarozole Hydrochloride category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.