Cancer Terms

Lobradimil

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Adjuvant -> Lobradimil

Lobradimil Definition

A synthetic analog of bradykinin. Lobradimil is a potent, specific bradykinin B-2 receptor agonist that stimulates B-2 receptors expressed on the surface of brain capillary endothelial cells, thereby reversibly increasing the permeability of the blood-brain barrier (BBB). Compared to bradykinin, this agent possesses enhanced receptor selectivity, greater plasma stability, and a longer half-life. (NCI04)

Lobradimil Synonyms

Lobradimil, Cereport, DRG-0182, L-Prolinamide, L-Arginyl-L-prolyl-trans-4- hydroxy-L-prolyl-3-(2- thienyl)-L-alanylglycl -L-seryl-N-(2-((4-((aminoiminomethyl)amino)-1- -carboxybutyl)amino)-1-((4-methoxyphenyl)methyl)ethyl)-, (S-(R*,R*)), LABRADIMIL, Labradimil, RMP-7, lobradimil

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