Lurtotecan
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Enzyme Inhibitor ->
Topoisomerase Inhibitor ->
Topoisomerase-I Inhibitor ->
Camptothecin Analogue -> Lurtotecan
Lurtotecan Definition
A semisynthetic analogue of camptothecin with antineoplastic activity. Lurtotecan selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. Independent from DNA replication inhibition, lurtotecan also inhibits RNA synthesis, multi-ubiquitination and degradation of topoisomerase I and chromatin reorganization.
Lurtotecan Synonyms
Lurtotecan, 7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin, GG 211, GI147211, GI147211C, OSI-211, lurtotecan
Terms in Lurtotecan category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.