MADD Protein

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Signaling Protein -> Adaptor Signaling Protein -> MADD Protein

MADD Protein Definition

Encoded by MADD Gene, MADD Protein Isoforms A-G are expressed in adult testis, ovary, brain, heart, and fetal brain and kidney. The 1588-amino acid 176.6-kD isoform D is full-length. Most variants involve 2-4 stretches of 18-43 amino acids in the central region. Isoforms F and G have a different C-terminus. Containing a C-terminal death domain, RGD motif, and a leucine zipper-like motif, SER- and LEU-rich membrane-bound MADD adaptor protein interacts with TNFR1 death domain to propagate apoptotic signaling. MADD can activate ERK2 and JNK1 MAP kinases and induce phosphorylation of Phospholipase A2. MADD appears to link TNFR1 with MAP kinase activation and arachidonic acid release. (from LocusLink, Swiss-Prot, OMIM, and NCI)

MADD Protein Synonyms

MADD Protein, Differentially Expressed in Normal and Neoplastic Cells Protein, Insulinoma-Glucagonoma Protein 20, MADD, MAP Kinase-Activating Death Domain Protein, MAP-Kinase Activating Death Domain-Containing Protein

MADD Protein

MADD Protein Definition

MADD Protein Synonyms

Terms in MADD Protein category