MAP-Kinase Kinase Kinase 8
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Mitogen-Activated Protein Kinase -> MAP-Kinase Kinase Kinase 8
MAP-Kinase Kinase Kinase 8 Definition
Encoded by human MAP3K8 Gene (MAP3K Family), cytoplasmic 58-kD (S and G2/M phase specific) and 52-kD isoforms of (Ser/Thr) MAP Kinase Kinase Kinase 8, produced by alternative initiation, activate MAP kinase and JNK kinase pathways in cell cycle regulation. Ser/Thr and autophosphorylated p38 MAPK activates IKB kinases, inducing proteasome-mediated proteolysis of cytoplasmic NFKB and nuclear translocation, and promotes TNF-alpha and IL-2 production during T lymphocyte activation. (NCI)
MAP-Kinase Kinase Kinase 8 Synonyms
MAP Kinase Kinase Kinase 8, C-COT, COT Gene Product, COT Proto-Oncogene Serine/Threonine-Protein Kinase, Cancer Osaka Thyroid Oncogene Protein, Ewing Sarcoma Transformant, Ewing Sarcoma Transformant; EST, MAP3K8, MAP3K8 Kinase, Mitogen-Activated Protein Kinase Kinase Kinase 8, p38 MAPK
Terms in MAP-Kinase Kinase Kinase 8 category
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