MAP-Kinase-10

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> Mitogen-Activated Protein Kinase -> MAP-Kinase-10

MAP-Kinase-10 Definition

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. (LocusLink)

MAP-Kinase-10 Synonyms

MAP Kinase 10, C-Jun N-Terminal Kinase 3, MAP Kinase P49 3F12, MAPK10, Stress Activated Protein Kinase Beta, Stress-Activated Protein Kinase JNK3, c-Jun Kinase 3

MAP-Kinase-10

MAP-Kinase-10 Definition

MAP-Kinase-10 Synonyms

Terms in MAP-Kinase-10 category