Cancer Terms

MAP-Kinase-14

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> Mitogen-Activated Protein Kinase -> MAP-Kinase-14

MAP-Kinase-14 Definition

Expressed in brain, heart, placenta, pancreas, skeletal muscle, lung, liver, and kidney, by human MAPK14 Gene (MAPK Family), the four isoforms (varying by internal segments and C-termini) of (Ser/Thr) Mitogen-Activated Protein Kinase 14 are involved in oxidative/hypoxic/environmental/genotoxic stress, transcription, cell cycle regulation, and apoptosis. Bound to cytoplasmic PTPRR and activated by cell stress, proinflammatory cytokines, LPS, Thr/Tyr phosphorylation by MAP2K3, MAP2K6, and MAP2K4, and autophosphorylation by MAP3K7IP1/TAB1 interaction, p38 MAPK phosphorylates MAPKAPK2, MAPKAPK5, ELK-1, ATF2, MEF2C, MAX, CDC25B, and p53. p38 is inhibited by DUSP1 and CSAID drugs. (NCI)

MAP-Kinase-14 Synonyms

MAP Kinase 14, CSAIDS Binding Protein, CSBP, Cytokine Suppressive Anti-Inflammatory Drug Binding Protein, MAP Kinase Mxi2, MAP Kinase p38Alpha, MAPK14, MAX-Interacting Protein 2, Mitogen-Activated Protein Kinase 14, Mitogen-Activated Protein Kinase p38Alpha, SAPK2A, Stress-Activated Protein Kinase 2A, p38 MAP Kinase, p38 MAPK, p38 Mitogen Activated Protein Kinase, p38Alpha EXIP

Terms in MAP-Kinase-14 category



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