MAP-Kinase-7

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> Mitogen-Activated Protein Kinase -> MAP-Kinase-7

MAP-Kinase-7 Definition

Highly expressed as four alternative transcripts in heart, placenta, lung, kidney, and skeletal muscle by human MAPK7 Gene (MAPK Family), 815-aa 88.6-kDa MAP Kinase 7 is a Ser/Thr kinase specifically activated by MAP2K5 (not MEK1/MEK2) and involved as an integration point for multiple downstream signals of various receptors, including receptor type kinases and GPCRs, in cell proliferation, differentiation, transcription regulation, and development. Autophosphorylated and likely activated by tyrosine and threonine phosphorylation by upstream kinase, MAPK7 translocates to the nucleus in response to extracellular signals and regulates gene expression by phosphorylating and activating target transcription factors. The C-terminus may have an autoregulatory role, and the second Pro-rich region may interact with actin, targeting MAPK7 to specific cell locations. (NCI)

MAP-Kinase-7 Synonyms

MAP Kinase 7, BMK1 Kinase, Extracellular Signal-Regulated Kinase 5, MAPK7

MAP-Kinase-7

MAP-Kinase-7 Definition

MAP-Kinase-7 Synonyms

Terms in MAP-Kinase-7 category