MAP-Kinase-8

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> Mitogen-Activated Protein Kinase -> MAP-Kinase-8

MAP-Kinase-8 Definition

Encoded by Human MAPK8 Gene (MAPK Family) as alternative isoforms (alpha-1, -2, beta-1, -2), MAP Kinase 8 is a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Beta-1 binds c-Jun; alpha-1, -2, and beta-2 bind c-Jun or ATF2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK8 mediates immediate-early gene expression. MAPK8 binds scaffolding proteins MAPK8IP1/2/3. MAPK8/UV-induced apoptosis appears related to cytochrome c-mediated cell death. MAPK8 activation by TNF-alpha induces apoptosis. MAPK8 appears to be required for T-helper cell differentiation into Th1 cells. (NCI)

MAP-Kinase-8 Synonyms

MAP Kinase 8, JN Kinase, JNK1 Protein, MAPK8, SAPK/JNK, SAPK1, SAPK1/JNK, Stress-Activated Protein Kinase 1, c-JUN N-Terminal Kinase

MAP-Kinase-8

MAP-Kinase-8 Definition

MAP-Kinase-8 Synonyms

Terms in MAP-Kinase-8 category