MAP-Kinase-9

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Serine-Threonine Protein Kinase -> Mitogen-Activated Protein Kinase -> MAP-Kinase-9

MAP-Kinase-9 Definition

Expressed as alpha-1, -2, beta-1, -2 isoforms by human MAPK9 Gene (MAPK Family), MAP Kinase 9 is a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Alpha-1, and 2 bind c-Jun; beta-1 and 2 bind ATF2. JunB and JunD are not substrates for alpha-2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK9 mediates immediate-early gene expression. MAPK9 binds scaffolding proteins MAPK8IP1/2/3. MAPK9/UV-induced apoptosis appears related to cytochrome c-mediated cell death. Increased p53 stability in nonstressed cells results from MAPK9 blocked p53 ubiquitination. MAPK9 appears required for T-helper cell differentiation into Th1 cells. (NCI)

MAP-Kinase-9 Synonyms

MAP Kinase 9, C-Jun Kinase 2, C-Jun N-Terminal Kinase 2, Jun Kinase, MAPK9, Stress-Activated Protein Kinase JNK2

MAP-Kinase-9

MAP-Kinase-9 Definition

MAP-Kinase-9 Synonyms

Terms in MAP-Kinase-9 category