Cancer Terms

MAX Interacting Protein-1

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Regulatory Protein -> Transcription Regulatory Protein -> Transcription Repressor Corepressor -> MAX Interacting Protein-1

MAX Interacting Protein-1 Definition

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. MAX Interacting Protein 1, encoded by the MXI1 gene, is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Two transcript variants encoding different isoforms have been identified for the MXI1 gene. (from LocusLink and NCI)

MAX Interacting Protein-1 Synonyms

MAX Interacting Protein 1, MAD, MAD Protein, MAD Protein (MAX-Binding Protein), MAX Dimerization Protein, MAX Dimerization Protein 2, MAX Dimerizer, MAX-Interacting Protein 1, MXD1, MXI1

Terms in MAX Interacting Protein-1 category



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