MDM2 wt Allele

Cancer Terms -> Gene -> Ligand Binding Protein Gene -> MDM2 Gene -> MDM2 wt Allele

MDM2 wt Allele Definition

Human MDM2 wild-type allele is located within 12q14.3-q15 and is approximately 32 kb in length. This allele, which encodes ubiquitin-protein ligase E3 Mdm2 protein, plays a role in the regulation of transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53 and diminish its tumor suppressor capability.

MDM2 wt Allele Synonyms

MDM2 wt Allele, MDM 2, MDM2, Transformed 3T3 Cell Double Minute 2, p53 Binding Protein (Mouse) wt Allele, p53-Binding Protein Gene

Terms in MDM2 wt Allele category

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