Cancer Terms

MET Tyrosine Kinase Inhibitor PF-04217903

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Enzyme Inhibitor -> Protein Kinase Inhibitor -> Tyrosine Kinase Inhibitor -> MET Tyrosine Kinase Inhibitor PF-04217903

MET Tyrosine Kinase Inhibitor PF-04217903 Definition

An orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-04217903 selectively binds to and inhibits mesenchymal epithelial transition (MET or c-Met), disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met. The receptor tyrosine kinase c-Met, also known as hepatocyte growth factor (HGF) receptor, is overexpressed or mutated in many tumor cell types, playing an important role in tumor cell proliferation, survival, invasion, and metastasis and angiogenesis.

MET Tyrosine Kinase Inhibitor PF-04217903 Synonyms

MET Tyrosine Kinase Inhibitor PF-04217903, PF-04217903

Terms in MET Tyrosine Kinase Inhibitor PF-04217903 category



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