MGMT wt Allele
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MGMT wt Allele Definition
Human MGMT wild-type allele is located within 10q26 and is approximately 300 kb in length. This allele, which encodes methylated-DNA--protein-cysteine methyltransferase protein, plays a role in the repair of O6-alkylguanine residues in DNA. Expression of the MGMT gene is abrogated via promoter hypermethylation in certain types of cancer such as brain neoplasms, gastric cancer, hepatocellular carcinoma and non-small cell lung cancer.
MGMT wt Allele Synonyms
MGMT wt Allele, Methylguanine-DNA Methyltransferase Gene, O-6-Methylguanine-DNA Methyltransferase wt Allele
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