Mannose-Binding Lectin

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Biological Response Modifier -> Miscellaneous Biologic Response Modifier -> Mannose-Binding Lectin

Mannose-Binding Lectin Definition

A recombinant protein similar or identical to human Mannan-binding lectin (MBL) that plays an important role in the innate immune defence. MBL is a plasma protein containing a carbohydrate recognition domain at one end and a collagen-like stalk domain at the other. The presence of multiple carbohydrate binding sites in a single molecule of MBL allows strong affinity to microorganisms. Upon binding, activation of the complement system leads to the deposition of complement components on the surface of the microorganisms (opsonisation) and to the clearance of the microorganisms by phagocytic cells. Administration of the agent to deficient individuals may restore lectin function in vivo, and thereby be beneficial in management of the immunodeficiency.

Mannose-Binding Lectin Synonyms

Mannose-Binding Lectin, MBL, MBP, Mannan-Binding Lectin, Mannose Binding Protein

Mannose-Binding Lectin

Mannose-Binding Lectin Definition

Mannose-Binding Lectin Synonyms

Terms in Mannose-Binding Lectin category