Map Kinase Inactivation of SMRT Corepressor Pathway
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Map Kinase Inactivation of SMRT Corepressor Pathway Definition
Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is represented in this pathway. The EFG receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by either pathway causes SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF.
Map Kinase Inactivation of SMRT Corepressor Pathway Synonyms
Map Kinase Inactivation of SMRT Corepressor Pathway, Map Kinase Inactivation of SMRT Corepressor
Terms in Map Kinase Inactivation of SMRT Corepressor Pathway category
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