Matrigel Invasion Assay

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Matrigel Invasion Assay Definition

Matirgel is considered as basement membrane and generated from EHS sarcoma. Matrigel contains not only basement membrane components (collagens, laminin, and proteoglycans) but also matrix degrading enzymes/their inhibitors and growth factors. Invasion of tumor cells into Matrigel has been used to characterize involvement of ECM receptors and matrix degrading enzymes which play roles in tumor progression. Matrix metalloproteinases (MMPs) are a family of enzymes known to degrade components of the extracellular matrix (ECM) and their activity and secretion have been implicated in tumor invasion.