Matriptase

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Hydrolase -> Protease -> Serine Protease -> Matriptase

Matriptase Definition

Expressed in prostate, kidney, lung, small intestine, stomach, colon, placenta, spleen, liver, leukocytes, and thymus, human ST14 Gene (Peptidase S1 Family) encodes an 855-aa 95-kD membrane-associated serine protease, Matriptase. ST14 contains an N-region integrin-binding site, N-glycosylation sites, tandem LDLR class A cysteine repeats, CUB domains, a putative proteolytic activation site, a C-terminal trypsin-like serine protease region, an S1 pocket, an S2 subsite, and an S4 cavity. Protease specificity involves additional cleavage site residues. Complexed with 40-kD SPINT1, a Kunitz-type inhibitor, ST14 is activated by sphingosine 1-phosphate, degrades extracellular matrix, and cleaves/activates HGF and urokinase plasminogen activator. ST14 may play a role in cancer invasion and metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)

Matriptase Synonyms

Matriptase, Epithin, MT-SP1, Membrane-Type Serine Protease 1, Prostamin, ST14, Serine Protease TADG-15, Suppression of Tumorigenicity 14, Suppressor of Tumorigenicity 14, Tumor Associated Differentially Expressed Gene 15 Protein

Matriptase

Matriptase Definition

Matriptase Synonyms

Terms in Matriptase category