Cancer Terms

Matrix Metalloproteinase-2

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Matrix Metalloproteinase-2 Definition

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This enzyme degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. (from LocusLink)

Matrix Metalloproteinase-2 Synonyms

Matrix Metalloproteinase 2, 72kD type IV Collagenase, Gelatinase A, Gelatinase Neutrophil, MMP2, PEX

Terms in Matrix Metalloproteinase-2 category



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