Cancer Terms

Matrix Metalloproteinase-9

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Matrix Metalloproteinase-9 Definition

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This enzyme degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (from LocusLink)

Matrix Metalloproteinase-9 Synonyms

Matrix Metalloproteinase-9, Gelatinase B, MMP-9 Protein, MMP9, Macrophage Gelatinase, Type V Collagenase

Terms in Matrix Metalloproteinase-9 category



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