Megakaryocyte-Associated Tyrosine Kinase

Cancer Terms -> Gene Product -> Protein -> Protein Organized by Function -> Enzyme -> Transferase -> Phosphotransferase -> Kinase -> Protein Kinase -> Protein Tyrosine Kinase -> Megakaryocyte-Associated Tyrosine Kinase

Megakaryocyte-Associated Tyrosine Kinase Definition

Expressed in various myeloid cells, brain, and lung by human MATK Gene (CSK Family), 507-aa 56-kDa cytoplasmic Megakaryocyte-Associated Tyrosine Kinase is similar to CSK tyrosine kinase. MATK contains an SH2 and SH3 domain, a catalytic domain, and a unique N-terminus; it lacks myristylation signals, a negative regulatory phosphorylation site, and an autophosphorylation site. Able to phosphorylate and inactivate SRC tyrosine kinases, MATK may regulate SRC activity in brain by phosphorylating the C-terminal negative regulatory tyrosine. Likely to play a significant role in signal transduction in hematopoietic cells, MATK may inhibit T-cell proliferation. (NCI)

Megakaryocyte-Associated Tyrosine Kinase Synonyms

Megakaryocyte-Associated Tyrosine Kinase, CHK, CSK-Homologous Kinase, CSK-Type Protein Tyrosine Kinase, CTK, HYL, HYL Tyrosine Kinase, Hematopoietic Consensus Tyrosine-Lacking Kinase, Hydroxyaryl-Protein Kinase, LSK, Leukocyte Carboxyl-Terminal Src Kinase Related Protein, MATK, Megakaryocyte-Associated Tyrosine-Protein Kinase, Protein Kinase HYL, Tyrosine Kinase MATK, Tyrosine-Protein Kinase CTK

Megakaryocyte-Associated Tyrosine Kinase

Megakaryocyte-Associated Tyrosine Kinase Definition

Megakaryocyte-Associated Tyrosine Kinase Synonyms

Terms in Megakaryocyte-Associated Tyrosine Kinase category