Cancer Terms

Melphalan

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Alkylating Agent -> Antineoplastic Alkylating Agent -> Mustard Agent -> Nitrogen Mustard Compound -> Melphalan

Melphalan Definition

An orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. (NCI04)

Melphalan Synonyms

Melphalan, 4-[bis(2-chloroethyl)amino]-L-phenylalanine, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-Phenylalanine mustard, L-Sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, L-sarcolysin, MELPHALAN, Melphalanum, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, Phenylalanine nitrogen mustard, Sarcoclorin, Sarkolysin, WR-19813, melphalan, p-di(chloroethyl)amino-L-phenylalanine

Terms in Melphalan category



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