Cancer Terms

Melphalan Hydrochloride

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Antineoplastic Agent -> Alkylating Agent -> Antineoplastic Alkylating Agent -> Mustard Agent -> Nitrogen Mustard Compound -> Melphalan Hydrochloride

Melphalan Hydrochloride Definition

A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death.

Melphalan Hydrochloride Synonyms

Melphalan Hydrochloride, 3-(p-(bis(2-chloroethyl)amino)phenyl)-L-Alanine, Hydrochloride, Alkeran, Alkerana, MELPHALAN HYDROCHLORIDE

Terms in Melphalan Hydrochloride category



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