Methionine Isoleucine Threonine and Valine Degradation Pathway

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Methionine Isoleucine Threonine and Valine Degradation Pathway Definition

The carbon chains of methionine, isoleucine, threonine, and valine are broken down to produce succinyl-CoA, which feeds into the Citric Acid Cycle. Methionine donates its methyl group via S-adenosylmethionine to one of several acceptors and the four remaining carbons are the backbone of propionyl-CoA that is subsequently converted to succinyl-CoA. The transdeamination and decarboxylation of valine are followed by a series of steps resulting in the formation of propionyl-CoA. Isoleucine also undergoes transdeamination, followed by oxidative decarboxylation. These steps yield propionyl-CoA as well as acetyl-CoA. Deficiency in the steps that convert isoleucine to propionyl-CoA causes sudden unexplained infant death, Reye-like syndrome, cardiomyopathy, and skeletal myopathy. (BioCarta)

Methionine Isoleucine Threonine and Valine Degradation Pathway Synonyms

Methionine, Isoleucine, Threonine and Valine Degradation Pathway, Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine

Methionine Isoleucine Threonine and Valine Degradation Pathway

Methionine Isoleucine Threonine and Valine Degradation Pathway Definition

Methionine Isoleucine Threonine and Valine Degradation Pathway Synonyms

Terms in Methionine Isoleucine Threonine and Valine Degradation Pathway category