Methylnaltrexone
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Methylnaltrexone Definition
A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, resulting in decreases in opioid-related constipation, urinary retention, and pruritis, respectively. Methylnaltrexone does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids.
Methylnaltrexone Synonyms
Methylnaltrexone, 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium, METHYLNALTREXONE, N-methylnaltrexone Bromide, Quaternary Ammonium Naltrexone
Terms in Methylnaltrexone category
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