Metolazone
Cancer Terms ->
Drugs and Chemicals ->
Pharmacologic Substance ->
Agent Affecting Blood And Body Fluid ->
Diuretic ->
Thiazide Diuretic -> Metolazone
Metolazone Definition
A sulfonamide derivative and a member of the quinazoline family, chemically related to thiazides, with diuretic, antihypertensive and antiurolithic properties. By blocking Na/Cl transporter, metolazone inhibits electrolyte reabsorption in the distal convoluted tubule and proximal tubule in the kidney. This prevents salt and fluid retention, leading to decreased plasma volume and reduce peripheral resistance of blood vessels, thereby reversal of hypertension.
Metolazone Synonyms
Metolazone, 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone, 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide, Diulo, METOLAZONE, Metenix, Mykrox, SR-720-22, Xuret, Zaroxolyn
Terms in Metolazone category
Copyright © Cancer Terms 2014 All rights reserved. | Terms of Use | Low Carb Foods
No reproduction or republication permitted.