Cancer Terms

Metolazone

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Blood And Body Fluid -> Diuretic -> Thiazide Diuretic -> Metolazone

Metolazone Definition

A sulfonamide derivative and a member of the quinazoline family, chemically related to thiazides, with diuretic, antihypertensive and antiurolithic properties. By blocking Na/Cl transporter, metolazone inhibits electrolyte reabsorption in the distal convoluted tubule and proximal tubule in the kidney. This prevents salt and fluid retention, leading to decreased plasma volume and reduce peripheral resistance of blood vessels, thereby reversal of hypertension.

Metolazone Synonyms

Metolazone, 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone, 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide, Diulo, METOLAZONE, Metenix, Mykrox, SR-720-22, Xuret, Zaroxolyn

Terms in Metolazone category



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