Cancer Terms

Midodrine Hydrochloride

Cancer Terms -> Drugs and Chemicals -> Pharmacologic Substance -> Agent Affecting Nervous System -> Adrenergic Agent -> Alpha-adrenergic Agonist -> Midodrine Hydrochloride

Midodrine Hydrochloride Definition

The hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system.

Midodrine Hydrochloride Synonyms

Midodrine Hydrochloride, (+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide Monohydrochloride, 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol Hydrochloride, Amatine, Gutron, MIDODRINE HYDROCHLORIDE, Midamine, ProAmantine

Terms in Midodrine Hydrochloride category



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