Minichromosome Maintenance Protein-2
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Minichromosome Maintenance Protein-2 Definition
Minichromosome Maintenance Protein 2 (MCM2) is encoded by the MCM2 gene. This 100-kD nuclear protein allows the DNA to undergo a single round of replication per cell cycle and is required for the entry in S phase and for cell division. MCM4, MCM6, and MCM7 form a stable complex with which MCM2 is loosely associated. The trimeric complex of MCM4, -6, and -7 has ATPase and DNA helicase activities, which is involved in the initiation of DNA replication as a DNA unwinding enzyme. The presence of MCM2 disturbs the assembly of MCM4, MCM6, and MCM7 proteins to inhibit the DNA helicase activity. Through specific binding of MCM2 with histone H3, the complex binds chromatin. In addition, the CDC7L1 kinase complex triggers S phase by directly activating the replication initiation complex assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase. (NCI)
Minichromosome Maintenance Protein-2 Synonyms
Minichromosome Maintenance Protein 2, BM28, CCNL1, CDCL1, Cell Devision Cycle-Like 1, Cyclin-Like 1, D3S3194, DNA Replication Licensing Factor MCM2, KIAA0030, MCM2, MCM2 Minichromosome Maintenance Deficient 2, Mitotin (S. cerevisiae), MCM2 Protein, MGC10606, Minichromosome Maintenance, S. cerevisiae, Homolog of, 2, Mitotin, Nuclear Protein BM28, cdc19
Terms in Minichromosome Maintenance Protein-2 category
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