Minichromosome Maintenance Protein-3
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Minichromosome Maintenance Protein-3 Definition
Minichromosome Maintenance Protein 3, encoded by the MCM3 gene, is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. (From LocusLink)
Minichromosome Maintenance Protein-3 Synonyms
Minichromosome Maintenance Protein 3
Terms in Minichromosome Maintenance Protein-3 category
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