Cancer Terms

Mixed Lymphocyte Reaction Test

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Mixed Lymphocyte Reaction Test Definition

Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (usually measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with mitomycin C or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.

Mixed Lymphocyte Reaction Test Synonyms

Mixed Lymphocyte Reaction Test, Mixed Lymphocyte Culture, Mixed T Cells, B Cells

Terms in Mixed Lymphocyte Reaction Test category



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