Monoclonal Antibody CHIR-12 12
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Monoclonal Antibody CHIR-12 12 Definition
A monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies.
Monoclonal Antibody CHIR-12 12 Synonyms
Lucatumumab, CHIR-12.12, HCD-122, Monoclonal Antibody CHIR-12.12
Terms in Monoclonal Antibody CHIR-12 12 category
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