Monoclonal Antibody KW-2871
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Monoclonal Antibody KW-2871 Definition
A low-fucose, human-mouse chimeric IgG1 monoclonal antibody with potential antineoplastic activity targeting at the ganglioside GD3, a surface antigen expressed on many malignant melanoma cells. Monoclonal antibody KW-2871 binds to GD3-positive cells, thereby initiating antibody-dependent cytotoxicity against GD3-positive cells. This agent is prepared by fusing murine immunoglobulin (Ig) light and heavy variable regions derived from the murine IgG3 antibody KM-641 to a human constant (Fc) region. The low fucose content of the oligosaccharide side chains of this antibody may enhance binding of the antibody Fc region to lymphocyte Fc receptors.
Monoclonal Antibody KW-2871 Synonyms
Monoclonal Antibody KW-2871, Chimeric Monoclonal Antibody KW-2871
Terms in Monoclonal Antibody KW-2871 category
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